This is a story about two brothers. The older one, Lincoln Burrows, is a troubled guy and a former drug addict who is imprisoned in the high-security prison "Fox River" awaiting execution for the murder of the vice president, which he did not commit. The younger brother, Michael Scofield, decides to save his brother and organize an escape from the prison. To carry out the plan, Michael stages a fake bank robbery, refuses a lawyer, and voluntarily enters the same prison where his brother awaits execution. He used to work for a company that was involved in planning the "Fox River" facility and knows a lot of interesting details about all the rooms. All the necessary information is always with Michael, as he got an impressive tattoo on his body before going to prison. While Michael works on executing the plan inside the prison, getting acquainted with the local authorities, and preparing for the escape of the century, the childhood friend of the brothers, lawyer Veronica Donovan, conducts her own investigation into the vice president's murder. She tries to find out who framed Lincoln and who is behind the series of murders related to this case.